Obesity in male volcano mice Neotomodon alstoni affects the daily rhythm of metabolism and thermoregulation.

ABSTRACT: The mouse N. alstoni spontaneously develops the condition of obesity in captivity when fed regular chow. We aim to study the differences in metabolic performance and thermoregulation between adult lean and obese male mice. The experimental approach included indirect calorimetry using metabolic cages for VO₂ intake and VCO₂ production. In contrast, the body temperature was measured and analyzed using intraperitoneal data loggers. It was correlated with the relative presence of UCP1 protein and its gene expression from interscapular adipose tissue (iBAT). We also explored in this tissue the relative presence of Tyrosine Hydroxylase (TH) protein, the rate-limiting enzyme for catecholamine biosynthesis present in iBAT. Results indicate that obese mice show a daily

SUBMITTER: Herrera-Garcia A 

PROVIDER: S-EPMC9386375 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature