Meta-analysis of longitudinal neurocognitive performance in people at clinical high-risk for psychosis.

ABSTRACT: Persons at clinical high-risk for psychosis (CHR) are characterised by specific neurocognitive deficits. However, the course of neurocognitive performance during the prodromal period and over the onset of psychosis remains unclear. The aim of this meta-analysis was to synthesise results from follow-up studies of CHR individuals to examine longitudinal changes in neurocognitive performance. Three electronic databases were systematically searched to identify articles published up to 31 December 2021. Thirteen studies met inclusion criteria. Study effect sizes (Hedges' g) were calculated and pooled for each neurocognitive task using random-effects meta-analyses. We examined whether changes in performance between baseline and follow-up assessments differed between: (1) CHR and healthy c

SUBMITTER: Hedges EP 

PROVIDER: S-EPMC9386433 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature