Synthesis, biological activity and toxicity to zebrafish of benzamides substituted with pyrazole-linked 1,2,4-oxadiazole.

ABSTRACT: To find pesticidal lead compounds with high activity, a series of novel benzamides substituted with pyrazole-linked 1,2,4-oxadiazole was designed and synthesized by using the splicing principle of active substructures. The chemical structures of the target compounds were confirmed by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay showed that most compounds displayed good larvicidal activities against mosquito larvae at 10 mg L^-1. In particular, compound 12g exhibited obvious activity; its lethal rate reached up to 100% (at 5 mg L^-1) and 55% (at only 2 mg L^-1). Furthermore, compound 12f (70.6%) and 12h (100%) showed good fungicidal activities against Pyricularia oryzae, with EC₅₀ values of 8.28 and 5.49 μg mL^-

SUBMITTER: Shao Y 

PROVIDER: S-EPMC9386446 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature