Comprehensive characterization of immune landscape of Indian and Western triple negative breast cancers.

ABSTRACT:

Purpose

Triple-negative breast cancer (TNBC) is a heterogeneous disease with a significant challenge to effectively manage in the clinic worldwide. Immunotherapy may be beneficial to TNBC patients if responders can be effectively identified. Here we sought to elucidate the immune landscape of TNBCs by stratifying patients into immune-specific subtypes (immunotypes) to decipher the molecular and cellular presentations and signaling events of this heterogeneous disease and associating them with their clinical outcomes and potential treatment options.

Experimental design

We profiled 730 immune genes in 88 retrospective Indian TNBC samples using the NanoString platform, established immunotypes using non-negative matrix factorization-based machine learning approach, and validated

SUBMITTER: Korlimarla A 

PROVIDER: S-EPMC9386467 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature