Dose-dependent impact of enrofloxacin on broiler chicken gut resistome is mitigated by synbiotic application.

ABSTRACT: Fluoroquinolone agents are considered critical for human medicine by the World Health Organization (WHO). However, they are often used for the treatment of avian colibacillosis in poultry production, creating considerable concern regarding the potential spread of fluoroquinolone resistance genes from commensals to pathogens. Therefore, there is a need to understand the impact of fluoroquinolone application on the reservoir of ARGs in poultry gut and devise means to circumvent potential resistome expansion. Building upon a recent dose optimization effort, we used shotgun metagenomics to investigate the time-course change in the cecal microbiome and resistome of broiler chickens receiving an optimized dosage [12.5 mg/kg body weight (bw)/day], with or without synbiotic supplementation (Poultr

SUBMITTER: Temmerman R 

PROVIDER: S-EPMC9386515 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature