Bacterial extracellular vesicles control murine norovirus infection through modulation of antiviral immune responses.

ABSTRACT: Human norovirus is the primary cause of non-bacterial gastroenteritis globally and is the second leading cause of diarrheal deaths in children in developing countries. However, effective therapeutics which prevent or clear norovirus infection are not yet available due to a lack of understanding regarding norovirus pathogenesis. Evidence shows that noroviruses can bind to the surface of commensal bacteria, and the presence of these bacteria alters both acute and persistent murine norovirus infection through the modulation of host immune responses. Interestingly, norovirus-bacterial interactions also affect the bacteria by inducing bacterial stress responses and increasing the production of bacterial extracellular vesicles. Given the established ability of these vesicles to easily cross the

SUBMITTER: Bhar S 

PROVIDER: S-EPMC9386532 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature