Analysis of Cancer Survival Associated With Immune Checkpoint Inhibitors After Statistical Adjustment: A Systematic Review and Meta-analyses.

ABSTRACT:

Importance

Appropriate clinical decision-making relies on accurate data interpretation, which in turn relies on the use of suitable statistical models. Long tails and early crossover-2 features commonly observed in immune checkpoint inhibitor (ICI) survival curves-raise questions as to the suitability of Cox proportional hazards regression for ICI survival analysis. Cox proportional hazards-Taylor expansion adjustment for long-term survival data (Cox-TEL) adjustment may provide possible solutions in this setting.

Objective

To estimate overall survival and progression-free survival benefits of ICI therapy vs chemotherapy using Cox-TEL adjustment.

Data sources

A PubMed search was performed for all cataloged publications through May 22, 2022.

Study selection

The s

SUBMITTER: Lin EP 

PROVIDER: S-EPMC9386543 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature