Fabrication of hydrolase responsive diglycerol based Gemini amphiphiles for dermal drug delivery applications.

ABSTRACT: Since biocatalysts manoeuvre most of the physiological activities in living organisms and exhibit extreme selectivity and specificity, their use to trigger physicochemical change in polymeric architectures has been successfully used for targeted drug delivery. Our major interest is to develop lipase responsive nanoscale delivery systems from bio-compatible and biodegradable building blocks. Herein, we report the synthesis of four novel non-ionic Gemini amphiphiles using a chemo-enzymatic approach. A symmetrical diglycerol has been used as a core that is functionalised with alkyl chains for the creation of a hydrophobic cavity, and for aqueous solubility (polyethylene glycol) monomethyl ether (mPEG) is incorporated. Such systems can exhibit a varied self-assembly behaviour leading to the ob

SUBMITTER: Mittal A 

PROVIDER: S-EPMC9386574 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature