Pooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma.

ABSTRACT:

Objectives

To investigate the association between occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma (MM) in a large, consortium-based study.

Methods

We pooled data on 2854 cases and 10 743 controls from nine studies participating in the InterLymph consortium. Occupational exposures to benzene, toluene and xylene were assigned by a job-exposure matrix, coupled with 'correction' of exposure probability by self-reported or expert-assessed exposure from the individual studies. Cumulative intensity was calculated as the job-specific exposure intensity multiplied by job duration, summed across jobs. Associations were estimated using logistic regression, with inclusion of covariates for study matching factors and other potential confounders. We rep

SUBMITTER: De Roos AJ 

PROVIDER: S-EPMC9386620 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature