Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma.

ABSTRACT:

Purpose

The etiology of exfoliation glaucoma (XFG) is poorly understood. We aimed to identify a prediagnostic plasma metabolomic signature associated with XFG.

Methods

We conducted a 1:1 matched case-control study nested within the Nurses' Health Study and Health Professionals Follow-up Study. We collected blood samples in 1989-1990 (Nurses' Health Study) and 1993-1995 (Health Professionals Follow-up Study). We identified 205 incident XFG cases through 2016 (average time to diagnosis from blood draw = 11.8 years) who self-reported glaucoma and were confirmed as XFG cases with medical records. We profiled plasma metabolites using liquid chromatography-mass spectrometry. We evaluated 379 known metabolites (transformed for normality using probit scores) using multiple condition

SUBMITTER: Kang JH 

PROVIDER: S-EPMC9386645 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature