Synthesis and Evaluation of Pseudomonas aeruginosa ATP Synthase Inhibitors.

ABSTRACT: New antibiotics with unique biological targets are desperately needed to combat the growing number of resistant bacterial pathogens. ATP synthase, a critical protein found in all life, has recently become a target of interest for antibiotic development due to the success of the anti-tuberculosis drug bedaquiline, and while many groups have worked on developing drugs to target bacterial ATP synthase, few have been successful at inhibiting Pseudomonas aeruginosa (PA) ATP synthase specifically. PA is one of the leading causes of resistant nosocomial infections across the world and is extremely challenging to treat due to its various antibiotic resistance mechanisms for most commonly used antibiotics. Herein, we detail the synthesis and evaluation of a series of C1/C2 quinoline analogue

SUBMITTER: Ciprich JF 

PROVIDER: S-EPMC9386795 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature