Engineering Tough, Injectable, Naturally Derived, Bioadhesive Composite Hydrogels.

ABSTRACT: Engineering mechanically robust bioadhesive hydrogels that can withstand large strains may open new opportunities for the sutureless sealing of highly stretchable tissues. While typical chemical modifications of hydrogels, such as increasing the functional group density of crosslinkable moieties and blending them with other polymers or nanomaterials have resulted in improved mechanical stiffness, the modified hydrogels have often exhibited increased brittleness resulting in deteriorated sealing capabilities under large strains. Furthermore, highly elastic hydrogels, such as tropoelastin derivatives are highly expensive. Here, gelatin methacryloyl (GelMA) is hybridized with methacrylate-modified alginate (AlgMA) to enable ion-induced reversible crosslinking that can dissipate energy under s

SUBMITTER: Tavafoghi M 

PROVIDER: S-EPMC9386893 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature