Short-Term Test for Toxicogenomic Analysis of Ecotoxic Modes of Action in Lemna minor.

ABSTRACT: In the environmental risk assessment of substances, toxicity to aquatic plants is evaluated using, among other methods, the 7 dayLemna sp. growth inhibition test following the OECD TG 221. So far, the test is not applicable for short-term screening of toxicity, nor does it allow evaluation of toxic modes of action (MoA). The latter is also complicated by the lack of knowledge of gene functions in the test species. Using ecotoxicogenomics, we developed a time-shortened 3 day assay inLemna minor which allows discrimination of ecotoxic MoA. By examining the changes in gene expression induced by low effect concentrations of the pharmaceutical atorvastatin and the herbicide bentazon at the transcriptome and proteome levels, we were able to identify candidate biomarkers for the res

SUBMITTER: Loll A 

PROVIDER: S-EPMC9386900 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature