The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in glioma.

ABSTRACT:

Background

Hexokinase 2 (HK2) is an enzyme that catalyses the conversion of glucose to glucose-6-phosphate, which has been found to be associated with malignant tumour growth. However, the potential immunological and clinical significance of HK2, especially in terms of prognostic prediction for patients with glioma, has not been fully elucidated.

Methods

To investigate the expression, immunological and clinical significance of HK2 in patients with glioma, several databases, including ONCOMINE, TIMER2.0, GEPIA, CGGA, UCSC, LinkedOmics, Metascape, STRING, GSCA, and TISIDB, as well as biochemical, cellular, and pathological analyses, were used in this study. In addition, we performed univariate, multivariate Cox regression and nomogram analyses of the hub genes positively and n

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9386956 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature