Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions.

ABSTRACT: Epigenetic modifications such as DNA methylation play an essential role in imprinting specific transcriptional patterns in cells. We performed genome-wide DNA methylation profiling of murine lymph node-derived ILCs, which led to the identification of differentially methylated regions (DMRs) and the definition of epigenetic marker regions in ILCs. Marker regions were located in genes with a described function for ILCs, such as Tbx21, Gata3, or Il23r, but also in genes that have not been related to ILC biology. Methylation levels of the marker regions and expression of the associated genes were strongly correlated, indicating their functional relevance. Comparison with T helper cell methylomes revealed clear lineage differences, despite partial similarities in the methylation of specific ILC

SUBMITTER: Beckstette M 

PROVIDER: S-EPMC9386974 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature