Clinical effectiveness and safety of self-expandable implantable bulking agents for faecal incontinence: a systematic review.

ABSTRACT:

Purpose

The purpose of this systematic review is to evaluate whether self-expandable implantable vs non-self-expandable injectable bulking agents (second-line therapies) are equal/superior in terms of effectiveness (severity, quality of life [QoL]) and safety (adverse events) for faecal incontinence (FI).

Methods

A systematic review was conducted, and five databases were searched (Medline via Ovid, Embase, Cochrane Library, University of York Centre for Reviews and Dissemination, and International Network of Agencies for Health Technology database). In-/exclusion criteria were predefined according to the PICOS scheme. The Institute of Health Economics risk of bias (RoB) tool assessed studies' internal validity. According to the Grading of Recommendations, Assessment, Develop

SUBMITTER: Gassner L 

PROVIDER: S-EPMC9386976 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature