Fungal diversity in the gut microbiome of young South African children.

ABSTRACT:

Background

The fungal microbiome, or mycobiome, is a poorly described component of the gut ecosystem and little is known about its structure and development in children. In South Africa, there have been no culture-independent evaluations of the child gut mycobiota. This study aimed to characterise the gut mycobiota and explore the relationships between fungi and bacteria in the gut microbiome of children from Cape Town communities.

Methods

Stool samples were collected from children enrolled in the TB-CHAMP clinical trial. Internal transcribed spacer 1 (ITS1) gene sequencing was performed on a total of 115 stool samples using the Illumina MiSeq platform. Differences in fungal diversity and composition in relation to demographic, clinical, and environmental factors were invest

SUBMITTER: Nel Van Zyl K 

PROVIDER: S-EPMC9387017 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature