Mesenchymal stem cells protect against TBI-induced pyroptosis in vivo and in vitro through TSG-6.

ABSTRACT:

Background

Pyroptosis, especially microglial pyroptosis, may play an important role in central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of mesenchymal stem cells (MSCs), such as human umbilical cord MSCs (hUMSCs), has been a focus of brain injury treatment. Recently, MSCs have been found to play a role in many diseases by regulating the pyroptosis pathway. However, the effect of MSC transplantation on pyroptosis following TBI remains unknown. Tumor necrosis factor α stimulated gene 6/protein (TSG-6), a potent anti-inflammatory factor expressed in many cell types including MSCs, plays an anti-inflammatory role in many diseases; however, the effect of TSG-6 secreted by MSCs on pyroptosis remains unclear.

Methods

Mice were subjected to

SUBMITTER: Feng Z 

PROVIDER: S-EPMC9387023 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature