Covid-19 and adolescent acute kidney injury: Renal recovery with combined enalapril and estrogen therapy.

ABSTRACT: Covid-19 in adolescence with multisystem inflammatory injury (MIS-C) is a newly described condition sharing key features with Kawasaki disease and toxic shock syndrome. A May 2020 United Nations WHO brief covering findings from North America and Europe drew notice to this acute post-viral illness characterized by severe, diffuse hyperinflammation leading to multiorgan failure. While females diagnosed with Covid-19 generally have more favorable outcomes than males, this protection is negated by a low estrogen state. This case reports on acute kidney injury/MIS-C with amenorrhea from ovarian insufficiency in childhood, itself an uncommon presentation of idiopathic hypogonadism. Three exon variants were previously identified in a healthy, phenotypically normal 46,XX adolescent who subsequentl

SUBMITTER: Sills ES 

PROVIDER: S-EPMC9387114 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature