Ets21C sustains a pro-regenerative transcriptional program in blastema cells of Drosophila imaginal discs.

ABSTRACT: An important unanswered question in regenerative biology is to what extent regeneration is accomplished by the reactivation of gene regulatory networks used during development versus the activation of regeneration-specific transcriptional programs. Following damage, Drosophila imaginal discs, the larval precursors of adult structures, can regenerate missing portions by localized proliferation of damage-adjacent tissue. Using single-cell transcriptomics in regenerating wing discs, we have obtained a comprehensive view of the transcriptome of regenerating discs and identified two regeneration-specific cell populations within the blastema, Blastema1 and Blastema2. Collectively, these cells upregulate multiple genes encoding secreted proteins that promote regeneration including Pvf1, upd3, asp

SUBMITTER: Worley MI 

PROVIDER: S-EPMC9387119 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature