Antibody feedback regulation of memory B cell development in SARS-CoV-2 mRNA vaccination.

ABSTRACT: Feedback inhibition of humoral immunity by antibodies was initially documented in guinea pigs by Theobald Smith in 1909, who showed that passive administration of excess anti-Diphtheria toxin inhibited immune responses¹. Subsequent work documented that antibodies can enhance or inhibit immune responses depending on antibody isotype, affinity, the physical nature of the antigen, and engagement of immunoglobulin (Fc) and complement (C') receptors^2,3. However, little is known about how pre-existing antibodies might influence the subsequent development of memory B cells. Here we examined the memory B cell response in individuals who received two high-affinity IgG1 anti-SARS-CoV-2 receptor binding domain (RBD)-specific monoclonal antibodies, C144-LS and C135-LS, and subseq

SUBMITTER: Schaefer-Babajew D 

PROVIDER: S-EPMC9387153 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature