Novel organisation and regulation of the pic promoter from enteroaggregative and uropathogenic Escherichia coli.

ABSTRACT: The serine protease autotransporters of the Enterobacteriaceae (SPATEs) are a large family of virulence factors commonly found in enteric bacteria. These secreted virulence factors have diverse functions during bacterial infection, including adhesion, aggregation and cell toxicity. One such SPATE, the Pic mucinase (protein involved in colonisation) cleaves mucin, allowing enteric bacterial cells to utilise mucin as a carbon source and to penetrate the gut mucus lining, thereby increasing mucosal colonisation. The pic gene is widely distributed within the Enterobacteriaceae, being found in human pathogens, such as enteroaggregative Escherichia coli (EAEC), uropathogenic E. coli (UPEC) and Shigella flexneri 2a. As the pic promoter regions from

SUBMITTER: Alhammadi MM 

PROVIDER: S-EPMC9387333 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature