Molecular hallmarks of heterochronic parabiosis at single-cell resolution.

ABSTRACT: The ability to slow or reverse biological ageing would have major implications for mitigating disease risk and maintaining vitality¹. Although an increasing number of interventions show promise for rejuvenation², their effectiveness on disparate cell types across the body and the molecular pathways susceptible to rejuvenation remain largely unexplored. Here we performed single-cell RNA sequencing on 20 organs to reveal cell-type-specific responses to young and aged blood in heterochronic parabiosis. Adipose mesenchymal stromal cells, haematopoietic stem cells and hepatocytes are among those cell types that are especially responsive. On the pathway level, young blood invokes new gene sets in addition to reversing established ageing patterns, with the global rescue of g

SUBMITTER: Palovics R 

PROVIDER: S-EPMC9387403 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature