Identification and profiling of stable microRNAs in hemolymph of young and old Locusta migratoria fifth instars.

ABSTRACT: Since the discovery of the first microRNA (miRNA) in the nematode Caenorhabditis elegans, numerous novel miRNAs have been identified which can regulate presumably every biological process in a wide range of metazoan species. In accordance, several insect miRNAs have been identified and functionally characterized. While regulatory RNA pathways are traditionally described at an intracellular level, studies reporting on the presence and potential role of extracellular (small) sRNAs have been emerging in the last decade, mainly in mammalian systems. Interestingly, evidence in several species indicates the functional transfer of extracellular RNAs between donor and recipient cells, illustrating RNA-based intercellular communication. In insects, however, reports on extracellular small RNA

SUBMITTER: Van den Brande S 

PROVIDER: S-EPMC9387440 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature