Frailty and Age Impact Immune Responses to Moderna COVID-19 mRNA Vaccine.

ABSTRACT:

Background

Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated with impaired antibody and cellular mRNA vaccine responses.

Methods

We followed older adults in a retirement facility with longitudinal clinical and serological samples from the first Moderna mRNA-1273 vaccine dose starting in February 2021 through their 3rd (booster) vaccine dose. Outcomes were antibody titers, antibody avidity, and AIM+ T cell function and phenotype. Statistical analysis used antibody titers in linear mixed-effects linear regression with clinical predictors including, age, sex, prior infection status, and clinical frailty scale (CFS) score. T cell function analysis used clinical predictors and cellular pheno

SUBMITTER: Semelka CT 

PROVIDER: S-EPMC9387536 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature