Reliability of Drug History to Verify Androgen Abuse in Men.

ABSTRACT:

Context

Clinical evaluations that require excluding androgen abuse, a secretive, illicit activity, rely on the drug history, but its veracity for androgen abuse has neither been verified nor has any objective corroborating laboratory test been validated.

Objective

In a high-risk population, to (a) validate the drug history of androgen abuse objectively using state-of-the-art World Anti-Doping Agency-accredited antidoping laboratory urine mass spectrometry tests and (b) to determine what biochemical tests best distinguish androgen abuse from nonuse in this population.

Methods

Urine samples from current (n = 41) and past (n = 31) androgen abusers and nonusers (n = 21) were analyzed by comprehensive mass spectrometry-based detection tests for androgens and related drugs

SUBMITTER: Shankara-Narayana N 

PROVIDER: S-EPMC9387685 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature