Genetic Variants Associated With Mineral Metabolism Traits in Chronic Kidney Disease.

ABSTRACT:

Context

Chronic kidney disease (CKD) causes multiple interrelated disturbances in mineral metabolism. Genetic studies in the general population have identified common genetic variants associated with circulating phosphate, calcium, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23).

Objective

In this study we aimed to discover genetic variants associated with circulating mineral markers in CKD.

Methods

We conducted candidate single-nucleotide variation (SNV) analysis in 3027 participants in the multiethnic Chronic Renal Insufficiency Cohort (CRIC) to determine the associations between SNVs and circulating levels of mineral markers.

Results

SNVs adjacent to or within genes encoding the regulator of G protein-coupled signaling 14 (RGS14) and the c

SUBMITTER: Laster ML 

PROVIDER: S-EPMC9387704 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature