Maternal Lipid Metabolism Is Associated With Neonatal Adiposity: A Longitudinal Study.

ABSTRACT:

Context

Pregnancy is characterized by progressive decreases in glucose insulin sensitivity. Low insulin sensitivity resulting in hyperglycemia is associated with higher neonatal adiposity. However, less is known regarding lipid metabolism, particularly lipid insulin sensitivity in pregnancy and neonatal adiposity.

Objective

Because higher maternal prepregnancy body mass index is strongly associated with both hyperlipidemia and neonatal adiposity, we aimed to examine the longitudinal changes in basal and clamp maternal lipid metabolism as contributors to neonatal adiposity.

Methods

Twelve women planning a pregnancy were evaluated before pregnancy, in early (12-14 weeks), and late (34-36 weeks) gestation. Body composition was estimated using hydrodensitometry. Basal and

SUBMITTER: Rojas-Rodriguez R 

PROVIDER: S-EPMC9387706 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature