Exploration of Streptococcus core genome to reveal druggable targets and novel therapeutics against S. pneumoniae.

ABSTRACT: Streptococcus pneumoniae (S. pneumoniae), the major etiological agent of community-acquired pneumonia (CAP) contributes significantly to the global burden of infectious diseases which is getting resistant day by day. Nearly 30% of the S. pneumoniae genomes encode hypothetical proteins (HPs), and better understandings of these HPs in virulence and pathogenicity plausibly decipher new treatments. Some of the HPs are present across many Streptococcus species, systematic assessment of these unexplored HPs will disclose prospective drug targets. In this study, through a stringent bioinformatics analysis of the core genome and proteome of S. pneumoniae PCS8235, we identified and analyzed 28 HPs that are common in many Streptococcus species and might have a potential role in the virulence or path

SUBMITTER: Chowdhury ZM 

PROVIDER: S-EPMC9387852 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature