A cortical thinning signature to identify World Trade Center responders with possible dementia.

ABSTRACT:

Introduction

World Trade Center (WTC) responders have a high risk of early-onset cognitive impairment (CI), but little is known about the etiology including the extent to which CI in WTC responders is accompanied by cortical atrophy as is common in progressive diseases causing age-related CI such as Alzheimer's disease and related dementias. In the current study, we entrained an artificial neural network (ANN) to determine the accuracy of cortical thickness (CTX) on magnetic resonance imaging to identify World Trade Center responders at midlife (aged 44-65 years) with possible dementia.

Methods

A total of 119 WTC responders (57 with CI and 62 with intact cognition) underwent a structural MRI scanning protocol including T1-weighted MPRAGE as part of two imaging studies. The d

SUBMITTER: Clouston SAP 

PROVIDER: S-EPMC9387912 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature