Functional compensation of mouse duplicates by their paralogs expressed in the same tissues.

ABSTRACT: Analyses in a number of organisms have shown that duplicated genes are less likely to be essential than singletons. This implies that genes can often compensate for the loss of their paralogs. However, it is unclear why the loss of some duplicates can be compensated by their paralogs, whereas the loss of other duplicates cannot. Surprisingly, initial analyses in mice did not detect differences in the essentiality of duplicates and singletons. Only subsequent analyses, using larger gene knockout datasets and controlling for a number of confounding factors, did detect significant differences. Previous studies have not taken into account the tissues in which duplicates are expressed. We hypothesized that in complex organisms, in order for a gene's loss to be compensated by one or more of its

SUBMITTER: Luzuriaga-Neira A 

PROVIDER: S-EPMC9387915 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature