RNA m⁶A demethylase ALKBH5 regulates the development of γδ T cells.

ABSTRACT: γδ T cells are an abundant T cell population at the mucosa and are important in providing immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T cells' origin in the thymus, detailed mechanisms regulating γδ T cell development remain poorly understood. N⁶-methyladenosine (m⁶A) represents one of the most common posttranscriptional modifications of messenger RNA (mRNA) in mammalian cells, but whether it plays a role in γδ T cell biology is still unclear. Here, we show that depletion of the m⁶A demethylase ALKBH5 in lymphocytes specifically induces an expansion of γδ T cells, which confers enhanced protection against gastrointestinal Salmonella typhimurium infection. Mechanistically, loss of ALKBH5 favors the develop

SUBMITTER: Ding C 

PROVIDER: S-EPMC9388086 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature