The circadian clock mediates daily bursts of cell differentiation by periodically restricting cell-differentiation commitment.

ABSTRACT: Most mammalian cells have an intrinsic circadian clock that coordinates metabolic activity with the daily rest and wake cycle. The circadian clock is known to regulate cell differentiation, but how continuous daily oscillations of the internal clock can control a much longer, multiday differentiation process is not known. Here, we simultaneously monitor circadian clock and adipocyte-differentiation progression live in single cells. Strikingly, we find a bursting behavior in the cell population whereby individual preadipocytes commit to differentiate primarily during a 12-h window each day, corresponding to the time of rest. Daily gating occurs because cells irreversibly commit to differentiate within only a few hours, which is much faster than the rest phase and the overall multiday differ

SUBMITTER: Zhang ZB 

PROVIDER: S-EPMC9388110 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature