Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.

ABSTRACT: Brain activity is constrained by local availability of chemical energy, which is generated through compartmentalized metabolic processes. By analyzing data of whole human brain gene expression, we characterize the spatial distribution of seven glucose and monocarboxylate membrane transporters that mediate astrocyte-neuron lactate shuttle transfer of energy. We found that the gene coding for neuronal MCT2 is the only gene enriched in cerebral cortex where its abundance is inversely correlated with cortical thickness. Coexpression network analysis revealed that MCT2 was the only gene participating in an organized gene cluster enriched in K[Formula: see text] dynamics. Indeed, the expression of K[Formula: see text] subunits, which mediate lactate increases with spiking activity, is spatially

SUBMITTER: Medel V 

PROVIDER: S-EPMC9388117 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature