A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
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ABSTRACT:
SUBMITTER: Ramdas S
PROVIDER: S-EPMC9388392 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
Ramdas Shweta S Judd Jonathan J Graham Sarah E SE Kanoni Stavroula S Wang Yuxuan Y Surakka Ida I Wenz Brandon B Clarke Shoa L SL Chesi Alessandra A Wells Andrew A Bhatti Konain Fatima KF Vedantam Sailaja S Winkler Thomas W TW Locke Adam E AE Marouli Eirini E Zajac Greg J M GJM Wu Kuan-Han H KH Ntalla Ioanna I Hui Qin Q Klarin Derek D Hilliard Austin T AT Wang Zeyuan Z Xue Chao C Thorleifsson Gudmar G Helgadottir Anna A Gudbjartsson Daniel F DF Holm Hilma H Olafsson Isleifur I Hwang Mi Yeong MY Han Sohee S Akiyama Masato M Sakaue Saori S Terao Chikashi C Kanai Masahiro M Zhou Wei W Brumpton Ben M BM Rasheed Humaira H Havulinna Aki S AS Veturi Yogasudha Y Pacheco Jennifer Allen JA Rosenthal Elisabeth A EA Lingren Todd T Feng QiPing Q Kullo Iftikhar J IJ Narita Akira A Takayama Jun J Martin Hilary C HC Hunt Karen A KA Trivedi Bhavi B Haessler Jeffrey J Giulianini Franco F Bradford Yuki Y Miller Jason E JE Campbell Archie A Lin Kuang K Millwood Iona Y IY Rasheed Asif A Hindy George G Faul Jessica D JD Zhao Wei W Weir David R DR Turman Constance C Huang Hongyan H Graff Mariaelisa M Choudhury Ananyo A Sengupta Dhriti D Mahajan Anubha A Brown Michael R MR Zhang Weihua W Yu Ketian K Schmidt Ellen M EM Pandit Anita A Gustafsson Stefan S Yin Xianyong X Luan Jian'an J Zhao Jing-Hua JH Matsuda Fumihiko F Jang Hye-Mi HM Yoon Kyungheon K Medina-Gomez Carolina C Pitsillides Achilleas A Hottenga Jouke Jan JJ Wood Andrew R AR Ji Yingji Y Gao Zishan Z Haworth Simon S Mitchell Ruth E RE Chai Jin Fang JF Aadahl Mette M Bjerregaard Anne A AA Yao Jie J Manichaikul Ani A Lee Wen-Jane WJ Hsiung Chao Agnes CA Warren Helen R HR Ramirez Julia J Bork-Jensen Jette J Kårhus Line L LL Goel Anuj A Sabater-Lleal Maria M Noordam Raymond R Mauro Pala P Matteo Floris F McDaid Aaron F AF Marques-Vidal Pedro P Wielscher Matthias M Trompet Stella S Sattar Naveed N Møllehave Line T LT Munz Matthias M Zeng Lingyao L Huang Jianfeng J Yang Bin B Poveda Alaitz A Kurbasic Azra A Schönherr Sebastian S Forer Lukas L Scholz Markus M Galesloot Tessel E TE Bradfield Jonathan P JP Ruotsalainen Sanni E SE Daw E Warwick EW Zmuda Joseph M JM Mitchell Jonathan S JS Fuchsberger Christian C Christensen Henry H Brody Jennifer A JA Le Phuong P Feitosa Mary F MF Wojczynski Mary K MK Hemerich Daiane D Preuss Michael M Mangino Massimo M Christofidou Paraskevi P Verweij Niek N Benjamins Jan W JW Engmann Jorgen J Noah Tsao L TL Verma Anurag A Slieker Roderick C RC Lo Ken Sin KS Zilhao Nuno R NR Kleber Marcus E ME Delgado Graciela E GE Huo Shaofeng S Ikeda Daisuke D DD Iha Hiroyuki H Yang Jian J Liu Jun J Demirkan Ayşe A Leonard Hampton L HL Marten Jonathan J Emmel Carina C Schmidt Börge B Smyth Laura J LJ Cañadas-Garre Marisa M Wang Chaolong C Nakatochi Masahiro M Wong Andrew A Hutri-Kähönen Nina N Sim Xueling X Xia Rui R Huerta-Chagoya Alicia A Fernandez-Lopez Juan Carlos JC Lyssenko Valeriya V Nongmaithem Suraj S SS Sankareswaran Alagu A Irvin Marguerite R MR Oldmeadow Christopher C Kim Han-Na HN Ryu Seungho S Timmers Paul R H J PRHJ Arbeeva Liubov L Dorajoo Rajkumar R Lange Leslie A LA Prasad Gauri G Lorés-Motta Laura L Pauper Marc M Long Jirong J Li Xiaohui X Theusch Elizabeth E Takeuchi Fumihiko F Spracklen Cassandra N CN Loukola Anu A Bollepalli Sailalitha S Warner Sophie C SC Wang Ya Xing YX Wei Wen B WB Nutile Teresa T Ruggiero Daniela D Sung Yun Ju YJ Chen Shufeng S Liu Fangchao F Yang Jingyun J Kentistou Katherine A KA Banas Bernhard B Morgan Anna A Meidtner Karina K Bielak Lawrence F LF Smith Jennifer A JA Hebbar Prashantha P Farmaki Aliki-Eleni AE Hofer Edith E Lin Maoxuan M Concas Maria Pina MP Vaccargiu Simona S van der Most Peter J PJ Pitkänen Niina N Cade Brian E BE van der Laan Sander W SW Chitrala Kumaraswamy Naidu KN Weiss Stefan S Bentley Amy R AR Doumatey Ayo P AP Adeyemo Adebowale A AA Lee Jong Young JY Petersen Eva R B ERB Nielsen Aneta A AA Choi Hyeok Sun HS Nethander Maria M Freitag-Wolf Sandra S Southam Lorraine L Rayner Nigel W NW Wang Carol A CA Lin Shih-Yi SY Wang Jun-Sing JS Couture Christian C Lyytikäinen Leo-Pekka LP Nikus Kjell K Cuellar-Partida Gabriel G Vestergaard Henrik H Hidalgo Bertha B Giannakopoulou Olga O Cai Qiuyin Q Obura Morgan O MO van Setten Jessica J He Karen Y KY Tang Hua H Terzikhan Natalie N Shin Jae Hun JH Jackson Rebecca D RD Reiner Alexander P AP Martin Lisa Warsinger LW Chen Zhengming Z Li Liming L Kawaguchi Takahisa T Thiery Joachim J Bis Joshua C JC Launer Lenore J LJ Li Huaixing H Nalls Mike A MA Raitakari Olli T OT Ichihara Sahoko S Wild Sarah H SH Nelson Christopher P CP Campbell Harry H Jäger Susanne S Nabika Toru T Al-Mulla Fahd F Niinikoski Harri H Braund Peter S PS Kolcic Ivana I Kovacs Peter P Giardoglou Tota T Katsuya Tomohiro T de Kleijn Dominique D de Borst Gert J GJ Kim Eung Kweon EK Adams Hieab H H HHH Ikram M Arfan MA Zhu Xiaofeng X Asselbergs Folkert W FW Kraaijeveld Adriaan O AO Beulens Joline W J JWJ Shu Xiao-Ou XO Rallidis Loukianos S LS Pedersen Oluf O Hansen Torben T Mitchell Paul P Hewitt Alex W AW Kähönen Mika M Pérusse Louis L Bouchard Claude C Tönjes Anke A Ida Chen Yii-Der YD Pennell Craig E CE Mori Trevor A TA Lieb Wolfgang W Franke Andre A Ohlsson Claes C Mellström Dan D Cho Yoon Shin YS Lee Hyejin H Yuan Jian-Min JM Koh Woon-Puay WP Rhee Sang Youl SY Woo Jeong-Taek JT Heid Iris M IM Stark Klaus J KJ Zimmermann Martina E ME Völzke Henry H Homuth Georg G Evans Michele K MK Zonderman Alan B AB Polasek Ozren O Pasterkamp Gerard G Hoefer Imo E IE Redline Susan S Pahkala Katja K Oldehinkel Albertine J AJ Snieder Harold H Biino Ginevra G Schmidt Reinhold R Schmidt Helena H Bandinelli Stefania S Dedoussis George G Thanaraj Thangavel Alphonse TA Peyser Patricia A PA Kato Norihiro N Schulze Matthias B MB Girotto Giorgia G Böger Carsten A CA Jung Bettina B Joshi Peter K PK Bennett David A DA De Jager Philip L PL Lu Xiangfeng X Mamakou Vasiliki V Brown Morris M Caulfield Mark J MJ Munroe Patricia B PB Guo Xiuqing X Ciullo Marina M Jonas Jost B JB Samani Nilesh J NJ Kaprio Jaakko J Pajukanta Päivi P Tusié-Luna Teresa T Aguilar-Salinas Carlos A CA Adair Linda S LS Bechayda Sonny Augustin SA de Silva H Janaka HJ Wickremasinghe Ananda R AR Krauss Ronald M RM Wu Jer-Yuarn JY Zheng Wei W den Hollander Anneke I AI Bharadwaj Dwaipayan D Correa Adolfo A Wilson James G JG Lind Lars L Heng Chew-Kiat CK Nelson Amanda E AE Golightly Yvonne M YM Wilson James F JF Penninx Brenda B Kim Hyung-Lae HL Attia John J Scott Rodney J RJ Rao D C DC Arnett Donna K DK Walker Mark M Scott Laura J LJ Koistinen Heikki A HA Chandak Giriraj R GR Mercader Josep M JM Villalpando Clicerio Gonzalez CG Orozco Lorena L Fornage Myriam M Tai E Shyong ES van Dam Rob M RM Lehtimäki Terho T Chaturvedi Nish N Yokota Mitsuhiro M Liu Jianjun J Reilly Dermot F DF McKnight Amy Jayne AJ Kee Frank F Jöckel Karl-Heinz KH McCarthy Mark I MI Palmer Colin N A CNA Vitart Veronique V Hayward Caroline C Simonsick Eleanor E van Duijn Cornelia M CM Jin Zi-Bing ZB Lu Fan F Hishigaki Haretsugu H Lin Xu X März Winfried W Gudnason Vilmundur V Tardif Jean-Claude JC Lettre Guillaume G T Hart Leen M LM Elders Petra J M PJM Rader Daniel J DJ Damrauer Scott M SM Kumari Meena M Kivimaki Mika M van der Harst Pim P Spector Tim D TD Loos Ruth J F RJF Province Michael A MA Parra Esteban J EJ Cruz Miguel M Psaty Bruce M BM Brandslund Ivan I Pramstaller Peter P PP Rotimi Charles N CN Christensen Kaare K Ripatti Samuli S Widén Elisabeth E Hakonarson Hakon H Grant Struan F A SFA Kiemeney Lambertus L de Graaf Jacqueline J Loeffler Markus M Kronenberg Florian F Gu Dongfeng D Erdmann Jeanette J Schunkert Heribert H Franks Paul W PW Linneberg Allan A Jukema J Wouter JW Khera Amit V AV Männikkö Minna M Jarvelin Marjo-Riitta MR Kutalik Zoltan Z Francesco Cucca C Mook-Kanamori Dennis O DO Willems van Dijk Ko K Watkins Hugh H Strachan David P DP Grarup Niels N Sever Peter P Poulter Neil N Huey-Herng Sheu Wayne W Rotter Jerome I JI Dantoft Thomas M TM Karpe Fredrik F Neville Matt J MJ Timpson Nicholas J NJ Cheng Ching-Yu CY Wong Tien-Yin TY Khor Chiea Chuen CC Li Hengtong H Sabanayagam Charumathi C Peters Annette A Gieger Christian C Hattersley Andrew T AT Pedersen Nancy L NL Magnusson Patrik K E PKE Boomsma Dorret I DI de Geus Eco J C EJC Cupples L Adrienne LA van Meurs Joyce B J JBJ Ikram Arfan A Ghanbari Mohsen M Gordon-Larsen Penny P Huang Wei W Kim Young Jin YJ Tabara Yasuharu Y Wareham Nicholas J NJ Langenberg Claudia C Zeggini Eleftheria E Tuomilehto Jaakko J Kuusisto Johanna J Laakso Markku M Ingelsson Erik E Abecasis Goncalo G Chambers John C JC Kooner Jaspal S JS de Vries Paul S PS Morrison Alanna C AC Hazelhurst Scott S Ramsay Michèle M North Kari E KE Daviglus Martha M Kraft Peter P Martin Nicholas G NG Whitfield John B JB Abbas Shahid S Saleheen Danish D Walters Robin G RG Holmes Michael V MV Black Corri C Smith Blair H BH Baras Aris A Justice Anne E AE Buring Julie E JE Ridker Paul M PM Chasman Daniel I DI Kooperberg Charles C Tamiya Gen G Yamamoto Masayuki M van Heel David A DA Trembath Richard C RC Wei Wei-Qi WQ Jarvik Gail P GP Namjou Bahram B Hayes M Geoffrey MG Ritchie Marylyn D MD Jousilahti Pekka P Salomaa Veikko V Hveem Kristian K Åsvold Bjørn Olav BO Kubo Michiaki M Kamatani Yoichiro Y Okada Yukinori Y Murakami Yoshinori Y Kim Bong-Jo BJ Thorsteinsdottir Unnur U Stefansson Kari K Zhang Jifeng J Chen Y Eugene YE Ho Yuk-Lam YL Lynch Julie A JA Tsao Philip S PS Chang Kyong-Mi KM Cho Kelly K O'Donnell Christopher J CJ Gaziano John M JM Wilson Peter P Mohlke Karen L KL Frayling Timothy M TM Hirschhorn Joel N JN Kathiresan Sekar S Boehnke Michael M Struan Grant Natarajan Pradeep P Sun Yan V YV Morris Andrew P AP Deloukas Panos P Peloso Gina G Assimes Themistocles L TL Willer Cristen J CJ Zhu Xiang X Brown Christopher D CD
American journal of human genetics 20220801 8
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow ...[more]
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