Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells.

ABSTRACT: Recurrent implantation failure (RIF) is defined as the failed pregnancy after good embryo transfer over 3 cycles during in vitro fertilization (IVF).The human endometrium plays a vital role in providing the site for embryo implantation, with several factors implicated in unsatisfactory endometrial receptivity in RIF. Our present results revealed that women with pregnancy loss or infertility have a higher serum epinephrine level, indicating a potential correlation between psychological stress and pregnancy failure. RNA-sequencing of the tissues collected at the endometrial receptive phase in normal and RIF women showed that stress hormones could affect the functional status of endometrial receptivity. Subsequent analysis revealed that the epinephrine signaling acts as an important regulator

SUBMITTER: Wu J 

PROVIDER: S-EPMC9388523 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature