Associations of genetic liability for Alzheimer's disease with cognition and eye movements in a large, population-based cohort study.

ABSTRACT: To identify cognitive measures that may be particularly sensitive to early cognitive decline in preclinical Alzheimer's disease (AD), we investigated the relation between genetic risk for AD and cognitive task performance in a large population-based cohort study. We measured performance on memory, processing speed, executive function, crystallized intelligence and eye movement tasks in 5182 participants of the Rhineland Study, aged 30 to 95 years. We quantified genetic risk for AD by creating three weighted polygenic risk scores (PRS) based on the genome-wide significant single-nucleotide polymorphisms coming from three different genetic association studies. We assessed the relation of AD PRS with cognitive performance using generalized linear models. Three PRS were associated with lower p

SUBMITTER: Coors A 

PROVIDER: S-EPMC9388528 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature