Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.

ABSTRACT:

Introduction

The mitochondrial genome has small open reading frames (sORF) which produce measurable mitochondrial-derived peptides (MDPs), including humanin, SHLP2, and MOTS-c. Previously, among men undergoing prostate biopsy, we found higher serum SHLP2 was linked with lower prostate cancer (PC) risk in European American men (EAM), while null associations were found in African American men (AAM). Here, in different patients undergoing prostate biopsy, we tested the link between SHLP2, humanin and MOTS-c and PC risk by race.

Methods

Plasma SHLP2, humanin, and MOTS-c were measured in 198 men (50/49 EAM/AAM cases; 50/49 EAM/AAM controls) undergoing biopsy. Logistic and multinomial regression models tested associations between each MDP and PC diagnosis, low-grade (grade group,

SUBMITTER: Ramirez-Torres A 

PROVIDER: S-EPMC9388542 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature