Antibody deposition on vascular endothelial cells contributes to localized inflammation in salivary glands.

ABSTRACT:

Background

Oral and ocular dryness due to reduced saliva and tear production, exocrine gland inflammation, and autoantibodies to multiple cellular proteins are the cardinal features of Sjögren's Disease. Among the autoantibody specificities, anti-Ro52 is linked with higher disease severity. We have previously reported that mice immunized with recombinant Ro52 developed IgG deposits in salivary and lacrimal glands and showed reduced saliva and tear production. Furthermore, passive transfer of sera from Ro52-immunized mice rapidly induced glandular dysfunction without immune cell infiltration in recipient mice.

Methods

To identify mechanisms driving antibody-mediated salivary gland dysfunction, hyperimmune rabbit antiserum to mouse Ro52 was passively transferred into NZM2758 f

SUBMITTER: Bagavant H 

PROVIDER: S-EPMC9388553 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature