PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.

ABSTRACT: Oligodendrogliomas are typically associated with the most favorable prognosis among diffuse gliomas. However, many of the tumors progress, eventually leading to patient death. To characterize the changes associated with oligodendroglioma recurrence and progression, we analyzed two recurrent oligodendroglioma tumors upon diagnosis and after tumor relapse based on whole-genome and RNA sequencing. Relapsed tumors were diagnosed as glioblastomas with an oligodendroglioma component before the World Health Organization classification update in 2016. Both patients died within 12 months after relapse. One patient carried an inactivating POLE mutation leading to a clearly hypermutated progressed tumor. Strikingly, both relapsed tumors carried focal chromosomal rearrangements in PTPRD and CNTNAP2 ge

SUBMITTER: Rautajoki KJ 

PROVIDER: S-EPMC9388569 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature