Validation of Monte Carlo ¹³¹ I radiopharmaceutical dosimetry workflow using a 3D-printed anthropomorphic head and neck phantom.

ABSTRACT:

Purpose

Approximately 50% of head and neck cancer (HNC) patients will experience loco-regional disease recurrence following initial courses of therapy. Retreatment with external beam radiotherapy (EBRT) is technically challenging and may be associated with a significant risk of irreversible damage to normal tissues. Radiopharmaceutical therapy (RPT) is a potential method to treat recurrent HNC in conjunction with EBRT. Phantoms are used to calibrate and add quantification to nuclear medicine images, and anthropomorphic phantoms can account for both the geometrical and material composition of the head and neck. In this study, we present the creation of an anthropomorphic, head and neck, nuclear medicine phantom, and its characterization for the validation of a Monte Carlo, SPECT ima

SUBMITTER: Adam DP 

PROVIDER: S-EPMC9388595 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature