Mitochondria-lysosome crosstalk in GBA1-associated Parkinson's disease.

ABSTRACT: Organelle crosstalk is significant in regulating their respective functions and subsequent cell fate. Mitochondria and lysosomes are amongst the essential organelles in maintaining cellular homeostasis. Mitochondria-lysosome connections, which may develop dynamically in the human neurons, have been identified as sites of bidirectional communication. Aberrancies are often associated with neurodegenerative disorders like Parkinson's disease (PD), suggesting the physical and functional link between these two organelles. PD is often linked with genetic mutations of several mutations discovered in the familial forms of the disease; some are considered risk factors. Many of these genes are either associated with mitochondrial function or belong to endo-lysosomal pathways. The recent investigatio

SUBMITTER: Sahyadri M 

PROVIDER: S-EPMC9388709 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature