Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC9388730 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Wang Yurong Y Liu Ling L Tan Chen C Meng Guiquan G Meng Lanlan L Nie Hongchuan H Du Juan J Lu Guang-Xiu GX Lin Ge G He Wen-Bin WB Tan Yue-Qiu YQ
Frontiers in genetics 20220805
<b>Background:</b> Infertility is a global health concern. <i>MEIOB</i> has been found to be associated with premature ovarian insufficiency (POI) and non-obstructive azoospermia (NOA), but its variants have not been reported in Chinese patients. The aim of this study was to identify the genetic aetiology of POI or NOA in three Han Chinese families. <b>Methods:</b> Whole-exome sequencing (WES) was used to identify candidate pathogenic variants in three consanguineous Chinese infertile families w ...[more]