Hedgehog/GLI signaling in hematopoietic development and acute myeloid leukemia-From bench to bedside.

ABSTRACT: While the underlying genetic alterations and biology of acute myeloid leukemia (AML), an aggressive hematologic malignancy characterized by clonal expansion of undifferentiated myeloid cells, have been gradually unraveled in the last decades, translation into clinical treatment approaches has only just begun. High relapse rates remain a major challenge in AML therapy and are to a large extent attributed to the persistence of treatment-resistant leukemic stem cells (LSCs). The Hedgehog (HH) signaling pathway is crucial for the development and progression of multiple cancer stem cell driven tumors, including AML, and has therefore gained interest as a therapeutic target. In this review, we give an overview of the major components of the HH signaling pathway, dissect HH functions in normal an

SUBMITTER: Tesanovic S 

PROVIDER: S-EPMC9388743 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature