Mendelian randomization supports the causal role of fasting glucose on periodontitis.

ABSTRACT:

Purpose

The effect of hyperglycemia on periodontitis is mainly based on observational studies, and inconsistent results were found whether periodontal treatment favors glycemic control. The two-way relationship between periodontitis and hyperglycemia needs to be further elucidated. This study aims to evaluate the causal association of periodontitis with glycemic traits using bi-directional Mendelian randomization (MR) approach.

Methods

Summary statistics were sourced from large-scale genome-wide association study conducted for fasting glucose (N = 133,010), HbA1c (N = 123,665), type 2 diabetes (T2D, N = 659,316), and periodontitis (N = 506,594) among European ancestry. The causal relationship was estimated using the inverse-variance weighted (IVW) model and further validated

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9388749 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature