A systematic review and meta-analysis of endocrine-related adverse events associated with interferon.

ABSTRACT:

Objectives

To perform a systematic review and meta-analysis of interferon and endocrine side effects, including their incidence, evaluation, and management.

Methods

PubMed was searched through March 7th, 2021, by 2 authors independently (LH Wang and H Zhao). Early phase I/II, phase III experimental trials, prospective and retrospective observational studies were included. Stata 16.0 (StataCorp LLC, 16.0) was the main statistical software for meta-analysis. The weighted incidence and risk ratio were estimated for primary thyroid disease and diabetes mellitus.

Results

A total of 108 studies involving 46265 patients were included. Hypothyroidism was the most common thyroid disorder, followed by hyperthyroidism. IFN α+RBV treated patients experienced hypothyroidism in 7.8

SUBMITTER: Wang L 

PROVIDER: S-EPMC9388759 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature