The impact of cathodal tDCS on the GABAergic system in the epileptogenic zone: A multimodal imaging study.

ABSTRACT:

Objectives

We aimed to investigate the antiepileptic effects of cathodal transcranial direct current stimulation (c-tDCS) and mechanisms of action based on its effects on the neurotransmitters responsible for the abnormal synchrony patterns seen in pharmacoresistant epilepsy. This is the first study to test the impact of neurostimulation on epileptiform interictal discharges (IEDs) and to measure brain metabolites in the epileptogenic zone (EZ) and control regions simultaneously in patients with pharmacoresistant epilepsy.

Methods

This is a hypothesis-driven pilot prospective single-blinded repeated measure design study in patients diagnosed with pharmacoresistant epilepsy of temporal lobe onset. We included seven patients who underwent two sessions of c-tDCS (sham followed

SUBMITTER: Abuhaiba SI 

PROVIDER: S-EPMC9388822 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature