The role of obesity, type 2 diabetes, and metabolic factors in gout: A Mendelian randomization study.

ABSTRACT:

Background

Several epidemiological studies have reported a possible correlation between risk of gout and metabolic disorders including type 2 diabetes, insulin resistance, obesity, dyslipidemia, and hypertension. However, it is unclear if this association is causal.

Methods

We used Mendelian randomization (MR) to evaluate the causal relation between metabolic conditions and gout or serum urate concentration by inverse-variance-weighted (conventional) and weighted median methods. Furthermore, MR-Egger regression and MR-pleiotropy residual sum and outlier (PRESSO) method were used to explore pleiotropy. Genetic instruments for metabolic disorders and outcome (gout and serum urate) were obtained from several genome-wide association studies on individuals of mainly European ance

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9388832 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature