Amyloid pathology induces dysfunction of systemic neurotransmission in aged APPswe/PS2 mice.

ABSTRACT: This study aimed to investigate how amyloid pathology affects the functional aspects of neurotransmitter systems in Alzheimer's disease. APPswe/PS2 mice (21 months of age) and wild-type (WT) mice underwent positron emission tomography (PET) and magnetic resonance spectroscopy (MRS). First, we obtained ¹⁸F-FDG and ¹⁸F-florbetaben PET scans to evaluate neuronal integrity and amyloid pathology. Second, ¹⁸F-FPEB and ¹⁸F-FMZ PET data were acquired to assess the excitatory-inhibitory neurotransmission. Third, to monitor the dopamine system, ¹⁸F-fallypride PET was performed. Amyloid PET imaging revealed that radioactivity was higher in the AD group than that in the WT group, which was validated by immunohistochemistry. In the cortical and lim

SUBMITTER: Oh SJ 

PROVIDER: S-EPMC9389227 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature