Plasma cells arise from differentiation of clonal lymphocytes and secrete IgM in Waldenstrom macroglobulinemia.

ABSTRACT: Waldenström macroglobulinemia (WM) is characterized by bone marrow infiltration with malignant lymphoplasmacytic cells (LPCs), a smaller population of plasma cells (PCs), and hypersecretion of IgM monoclonal protein. Here, we show that CD45^low, CD38⁺, and CD138⁺ PCs and CD45^high, CD38^-, CD138^-, CD19⁺, and CD20⁺ LPCs carry a heterozygous L265P mutation in the Toll-like receptor signaling adaptor MYD88. Both PCs and LPCs express the same auto-reactive IgHV sequences, suggesting a similar clonal origin and role for auto-antigens in WM cell survival. PCs are primarily responsible for IgM production even without substantial cell proliferation. When cultured in isolation, LPCs give rise to more differentiated

SUBMITTER: Lim JH 

PROVIDER: S-EPMC9389254 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature